China Drying News China is the world's third largest country in fine chemicals. The fine chemical industry is closely related to people's lives, especially organic functional compounds with complex structure and quality requirements, as well as fine chemicals such as "bombshells" grades that affect people's health.
Fine chemicals, including pharmaceuticals, pesticides, dyes, materials, and more than 40 industries, is the strategic focus of the development of the chemical industry in the world today. The Ministry of Commerce has included fine chemicals as one of the key development industries.
Organic synthesis challenges
The organic compounds with complex structures, such as fine chemicals represented by pharmaceuticals, pesticides, and other functional compounds, represent an important direction for modern industrial organic chemistry. The organic synthesis reaction and technology are the most important for obtaining these compounds. Direct means.
Fine chemical industry and organic synthesis technology complement each other. The lofty direction and goal of industrial organic synthesis is to use limited means and resources to produce fine chemicals with low cost and high quality with the most simple, economical, and environmentally-friendly means for a limited time.
The industrialization of fine chemicals is not only a technical issue, but how to design and use these technologies is an art and economic issue. The details and systems and the integration of factors are the key to industrialization. Economic quality and “consistent†quality assurance are universal Pratt & Whitney's basic requirements.
Organic synthesis technology has the advantages of reliable reaction and flexible “cutting†of molecules, but due to the incompleteness of most organic chemical reactions, separation and purification, and corresponding energy consumption and wastes, etc., run through the entire process of the entire industry. Purification and equipment form the core of modern organic industry. In general, more than 70% of the equipment in the industry, more than 50% of the material (energy) consumption, more than 30% of the separation and purification costs, and waste are generated during the separation and purification process, which leads to high energy consumption and environmental protection. And other issues.
Another major challenge for organic synthesis technology is selectivity (chemistry, stereo and chirality) and complexity. Selectivity and complexity mean diversity, instability, and risk. Challenges and solutions to these problems are innovative and revolutionary, and organic synthesis technology cannot solve these problems fundamentally because of the innate defects of reactivity and selectivity.
Biocatalysis becomes the new favorite
The modern biocatalysis technology represented by synthetic biology is highly efficient, highly selective, mild in transformation conditions, and environment-friendly. It can complete some reactions that are difficult to achieve with traditional chemical methods, thus becoming an alternative to sustainable development. And to expand the main methods of traditional chemical technology and are widely used in the preparation of various fine chemicals.
Industrial biocatalysis technology is regarded as the third wave of biotechnology development following agricultural and pharmaceutical biotechnology, and it is an important technology for achieving atomic economic response and greening the production process. Therefore, biocatalytic technology replaces traditional organic synthesis technologies and will find and find fertile ground for the industry in fine organic synthesis.
Two complementary technologies
Through cross-integration of biocatalysis and organic synthesis and complementary advantages, problems such as selectivity, environmental protection, and energy consumption of drug synthesis can be solved. Biotechnology is the ideal means to solve the problems of selectivity and complexity in chemical synthesis. The cross integration of biotechnology and organic synthesis will also become one of the main directions for the development of green pharmaceuticals.
The specificity of biocatalytic technology has led to the limitations of its application. Through the cross-combination and integration of organic synthesis and biocatalysis technologies, the industrial issues of fine chemicals have been solved, and it represents one of the main directions for the development of China's fine chemical industry. Organic synthesis technology identifies and provides more technological, product, and industrial opportunities for the development and application of biocatalytic technologies.
Cross-integration of biocatalysis and organic synthesis can be mainly carried out in two directions: targeting industrially influential products, developing suitable biocatalytic technologies, and industrializing and immobilizing existing mature research enzymes in the laboratory to speed up Promote the application of biocatalysis technology in the synthesis of fine chemicals.
Future development proposals
The development of China's biological (catalytic) technology should first be guided by influential industries (such as bio-pharmaceuticals, materials, fine chemicals) and industries, identify specific markets and products, and show large varieties (such as pesticides, basics). Chemicals, materials, etc. are the specific targets, and the relationship and mechanism for production, learning, research, government, and funding, transformation, incubation, and industrialization with Chinese characteristics should be established and straightened out as soon as possible, and the promotion of biological (catalytic) technologies from the long-term Research and planning will focus on the direction of the market, target and process-oriented industries; with enterprises as the main body, through the integration of factors, enhance the influence of the industry, improve product display, and promote the healthy development of the green fine chemical industry in China and the industry upgrade.
Biotechnology should aim at large varieties with clear market and industry influence and display, and transform traditional fine chemicals and related industries from resources, environmental protection, energy conservation and emission reduction, and carbon reduction through biocatalysis and process technology.
China has a pivotal position in the fields of pharmaceuticals, pesticides, foods, food additives, industrial surfactants, basic organic chemical raw materials, biological and biomedical materials and other fine and specialty chemicals. Any large variety and related industries are urgently required to pass biological Technology to transform traditional products and industries provides a major opportunity for the development and industrialization of biocatalytic technologies.
It is suggested to start from the cooperation mechanism and industrial division of labor to establish a professional research team and enterprise group for industrial application design, proceduralization, and industrialization of special enzymes; to set up a specialized cross-research direction in the biology and chemistry disciplines, and to guide product development and industry development. With the characteristics of enterprise participation and cross-disciplinarity, we will integrate system resources and establish a rapid reaction R&D and industrialization special force for biocatalysis technology in the bio-industry.
It is expected that in the next few years, the research of biocatalysis and organic synthesis integration technology will become a hot area of ​​China's technology development and industrialization. Chiral amino acids, chiral alcohols, and amine compounds are the main functional groups for constructing chiral medicines, pesticides, and materials. Hydrolytic enzymes, esterases, and oxidoreductases are among the most effective methods for constructing such compounds.
At the same time, it is ripe for laboratory research that can already be applied to the industrial application of lipases (such as Nov 435), oxidoreductases, nitrile hydrolases, transaminases, etc., especially in the pharmaceutical industry with industry influence, as well as product display The degree of bio-pesticides, materials and basic chemical and chemical industries should be given special attention to accelerate the process of industrialization of biological (catalytic) technologies in China.
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