Transdermal preparations: dosage forms are expected to reach three points in the world

Research on "transdermal delivery" of topical preparations has now begun in large-scale pharmaceutical manufacturing companies. Pharmaceutical expert and Xiong Weizheng, chairman of Henan Xianrui Pharmaceutical Co., Ltd., said at the 4th Academic Conference on Percutaneous Administration of External Preparations that modern "percutaneous administration" preparations are expected to be administered "3 Divided into the world."

Xiong Weizheng said that the "transdermal drug" formulation was incorporated into Ling Rui's strategic plan and implemented it. "This is mainly manifested in three major areas: the research and implementation of the production process of rubber ointment, the research and implementation of a new drug delivery technology platform for percutaneous pharmaceutical preparations, and the study and implementation of western medicine transdermal patches for the treatment of systemic diseases."

New "transdermal Chinese medicine" preparation

The "percutaneously administered" dosage forms are classified into traditional preparations (rubber creams, plasters) and modern preparations (paspages, gels, transdermal patches). Researchers believe that the traditional "transdermal Chinese medicine" preparations such as plasters, plasters, pastes, tinctures, etc., have a long history and many varieties. Long-term use shows that they are not containing harmful substances, pollute the environment, or are creamy. Thin layer, short duration of drug efficacy, poor air permeability, skin irritation, allergies and other shortcomings.

Nowadays, with the advancement of pharmaceutical technology and the use of new excipients for medical use, especially for the use of macromolecule pharmaceutical materials, coating agents, filming agents, cataplasms, sprays, patches, patches, etc. In accordance with the requirements of the modern “transdermal delivery of traditional Chinese medicine” research, researchers have studied the transdermal properties of traditional Chinese medicine, influencing factors, and absorption mechanisms, and have fully demonstrated the objective of the ancient method of transdermal delivery of Chinese medicine. At the same time, scientific connotation, and gave it a new vitality - the birth of a new "transdermal Chinese medicine" preparations.

It is understood that the modern “percutaneous administration of traditional Chinese medicine” has unique advantages over the general method of administration: it can pass through the “first-pass effect” of the liver and the destruction of the gastrointestinal tract, and is not affected by gastrointestinal enzymes, digestive juices, etc. The influence of factors, thereby increasing drug availability, providing a longer duration of action; reducing drug toxicity and side effects, maintaining a stable and long-lasting plasma concentration; high efficacy, ease of use, simple operation, and fewer administration times.

Xiong Weizheng said: "As the country's largest manufacturer of rubber ointment, Lingrui Pharmaceuticals organizes many resources to develop new 'transdermal medicines' preparations for Chinese medicine. This is not only the need for technological development and medical applications, but also the responsibility and obligation of the company. This will not only increase the added value of the product, but also meet the needs of different patients. At the same time, it can also be integrated with the foreign pharmaceutical industry."

Western medicine transdermal patch for treating systemic diseases

Nowadays, with the passage of time and advances in science and technology, a transdermal patch that is considered to be the most successful type of innovative drug has received a great deal of attention at home and abroad. It is a patch for an intact skin surface that can deliver drugs through the skin into the blood circulation system.

Relevant data show that there are currently 17 western medicine patches that have received the national approval number, and there are more than 35 “transdermal” formulations on the international market.

Predictions from the World Health Organization say that more than 30% of oral drugs need to be transdermally administered within the next 2-3 years.

Therefore, this type of drug market will accelerate growth due to the expansion of the number of drugs and the treatment field. The therapeutic field will also involve attention loss, hyperactivity disorder, Parkinson's disease, female sexual dysfunction, pain, osteoporosis, hormone replacement therapy, and the like.

In addition, transdermal drug delivery system drugs have also been widely welcomed in areas where traditional dosage forms dominate.

"The popularity of 7-day contraceptive drug delivery patch OrthoEvra shows that transdermal drug delivery can be used in a relatively mature therapeutic field. In 2002, the product became the second-best-selling drug in its kind, satisfying consumers. Needs. And before this kind of medicine was basically monopolized by the oral medicine." Xiong Weizheng said that he was a pharmacist expert.

He said: "Landry Pharmaceutical is actively considering the introduction of foreign products. It mainly includes two aspects: the introduction of foreign products with good efficacy and no domestic product; the introduction of domestic products with a lot number but low quality and technical level."

"We have cooperated with the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, and Kyoto University, Japan to develop a transdermal patch for chemical drugs. At present, there is a variety of new medicines for "percutaneous administration" and one type of matrix technology modification that have been applied to the State Drug Administration. registered."

Dosage form is expected to "three points of the world"

In recent years, great progress has been made in the basic theory research, experimental method research, new technology research, and clinical research of "Transdermal medicine of traditional Chinese medicine", especially for a variety of new excipients suitable for the traditional Chinese medicine transdermal preparations. The positive development of applied research made preparations for the preparation of Chinese medicines for the “transdermal delivery” preparation market.

Market research shows that in the next 10 years, the annual compound growth rate of the drug market for transdermal drug delivery systems will remain double-digit, far exceeding the average growth rate of the pharmaceutical industry. As a new type of drug delivery system, the rate of development of "transdermal drug delivery" formulations has been remarkable since its launch. Its market size has reached $12.7 billion in 2005.

"Transdermal patch is a kind of 'transdermal delivery' preparation. From a safety point of view, it should be a development direction." Executive Vice President of the Chinese Medicine New Drug Delivery System Professional Committee of the World Federation of Chinese Medicine Societies, Prof. Liang Bingwen, deputy director of the DDS pilot base of the National Engineering Research Center for New Drug Development at the National Center for New Drug Development of the Chinese Medicine New Drug Delivery System Professional Committee, said.

Some experts estimate that "transdermal drug" formulations will continue to develop rapidly in the next few years, with an average annual growth rate of 17.8%. By 2010, the dosage form market will reach $21.5 billion, and in 2015 it will reach 31.5 billion. The US dollar eventually formed the market situation of three major delivery forms of oral, injection and "transdermal delivery" preparations (mucosal).